Fertilization is the process by which the nucleus of a sperm (a male reproductive
cell) fuses (combines) with the nucleus of an egg (a female reproductive cell;
also called an ovum). Fertilization occurs somewhat differently in plants and
animals. In flowering plants, two sperm cells are involved in the process of
fertilization. The first sperm cell combines with an egg cell, while the second
sperm cell combines with two nuclei present in the ovule
(the structure that eventually becomes the seed). The structure formed in the
second fertilization eventually forms a storage site for nutrients needed by
the fertilized egg cells.
A fertilized
egg cell is known as a zygote. Once formed, the zygote undergoes continuous
cell division that eventually produces a new multicellular organism.
Sperm penetrating a hamster egg cell. (Reproduced
by permission of Photo Researchers, Inc.)
Fertilization in humans
In humans,
fertilization occurs in the fallopian tubes of the female reproductive tract.
It takes place within hours following sexual intercourse. Approximately 300
million sperm are released into a female's vagina during intercourse. However,
only one of these sperm can actually fertilize the single female egg cell (also
called an ovum). The successful sperm cell must enter the uterus and swim up
the fallopian tube to meet the egg cell. There it passes through the thick
coating surrounding the egg. This coating is known as the zona pellucida.
The head of the
sperm cell contains enzymes
(certain types of chemicals) that break through the zona pellucida and make it
possible for the sperm to penetrate into the egg. Once the head of the sperm is
inside the egg, the tail of the sperm falls off. The outside of the egg then
thickens to prevent another sperm from entering.
In humans, a
number of variables affect whether or not fertilization occurs following
intercourse. One factor is a woman's ovulatory
cycle. The ovulatory cycle is the series of events that bring about the ripening
of an egg and its release from the ovaries. Human eggs can be fertilized for
only a few days after ovulation, which usually occurs only once every 28 days.
Fertilization in other species
Nearly all
forms of terrestrial (land) animals use some form of internal fertilization
similar to that in humans. External fertilization, however, is more common
among aquatic animals. It is simple enough for aquatic animals simply to dump
their sperm and eggs into the water and let currents mix the two kinds of cells
with each other.
Reproduction of
the sea urchin is a typical example of external fertilization among aquatic
animals. A male sea urchin releases several billion sperm into the water. These
sperm then swim towards eggs released in the same area. Fertilization occurs
within seconds when sperm come into contact and fuse with eggs.
External fertilization in animals
Although it
does not occur naturally in animals very often, external fertilization is also
a possibility. In the case of humans, for example, some form of external
fertilization may be necessary when a male and female wish to have a child but
one or the other is biologically incapable of contributing to the normal
process of internal fertilization.
An example is
the process known as in vitro fertilization. The expression in vitro means
"in glass," that is, in a glass test tube or petri dish. The term is
used in contrast to in vivo fertilization, where in vivo means "in a
living organism."
During in vitro
fertilization, eggs are removed surgically from a female's reproductive tract.
Those eggs then can be fertilized by sperm that has been taken from a male and
then stored in a test tube or petri dish. After the fertilized eggs have
divided twice, they are reintroduced into the female's body. If all goes well,
the embryo
and fetus
develop, eventually resulting in a normal birth.
In vitro
fertilization has been performed successfully on a variety of domestic animals since the 1950s. In 1978, the
first human birth following in vitro fertilization occurred in England. Since
that time, the procedure has become a routine treatment for infertile couples
who wish to have children.
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